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人 IL-1R2/CD121b transcript variant 1 基因ORF全长cDNA克隆(表达载体)

  • Human IL1R2 / CD121b transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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 IL1R2 cDNA Clone产品信息
NCBI注册码:NM_004633.3
参考序列ORF长度:1197bp
cDNA基因描述:Full length Clone DNA of Homo sapiens interleukin 1 receptor, type I I, transcript variant 1.
分子别称:IL1R2, IL1RB, CD121b, MGC47725
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-IL1R2
限制性酶切位点:KpnI + XbaI (6.1kb + 1.2kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with IL1R2 qPCR primers for gene expression analysis, HP100186 )
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
 IL1R2 基因质粒图
Human IL1R2 / CD121b transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
人 IL-1R2/CD121b transcript variant 1 基因ORF全长cDNA克隆(表达载体) on other vectors
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研究背景

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

参考资料
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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    货号: HG10111-UT
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