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HIV  gp140

HIV  gp140 蛋白和抗体

GP140 蛋白GP140 抗体GP140 基因GP140 

HIV gp140 背景

Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses.The HIV-1 envelope glycoprotein gp160, also known as Glycoprotein 160, is cleaved into two chains: the surface protein gp120 and the transmembrane protein gp41. The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. Surface protein gp120 is a ligand for CD209 / DC-SIGN and CLEC4M / DC-SIGNR. It may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. The transmembrane protein gp41 (TM) acts as a class I viral fusion protein, and membranes fusion leads to delivery of the nucleocapsid into the cytoplasm. The external domains of the HIV-1 envelope glycoprotein (gp120 and the gp41 ectodomain, collectively known as gp140) contain all known viral neutralization epitopes.

HIV gp140 参考文献

  1. Robertson, DL. et al.,1995, J. Mol. Evol. 40 (3): 249-59.
  2. Gallo SA., et al., 2003, Biochim. Biophys. Acta. 1614: 36-50.
  3. Bobkov, AF. et al., 2004,?J. Med. Virol. 74 (2): 191-6.
  4. Yang X., J. et al., 2005, Virol. 79: 12132-47.
  5. Beddows, S. et al., 2007, Virology. 360 (2): 329-40.
  6. Du, SX. et al., 2009, Virology. 395 (1): 33-44.
  7. Mendu, DR. et al., 2007, Biochem Biophys Res Commun. 363 (3): 466-71.
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