LDLR cDNA ORF Clone, Human, N-HA tag

Cat: HG10231-NY
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LDLR cDNA ORF Clone, Human, N-HA tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
2583 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1440A/G, 1644C/T not causing the amino acid variation.
描述
Full length Clone DNA of Human low density lipoprotein receptor with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-SP-N-HA
限制性酶切位点
KpnI + XbaI (6kb + 2.61kb)
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
LDLR cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

LDLR cDNA ORF Clone, Human, N-HA tag Validated Images
Rhesus CD3d/CD3 delta Gene Plasmid Map 5616
LDLR cDNA ORF Clone, Human, N-HA tag Alternative Names
FH cDNA ORF Clone, Human;FHC cDNA ORF Clone, Human;LDL R cDNA ORF Clone, Human;LDL Receptor cDNA ORF Clone, Human;LDLCQ2 cDNA ORF Clone, Human
LDLR Background Information

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

Full Name
low density lipoprotein receptor
References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
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