CSF1R cDNA ORF Clone, Human, N-Myc tag

Cat: HG10161-NM
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All CSF1R Reagents
CRO Services
Product recommended

All CSF1R Reagents
CSF1R cDNA ORF Clone, Human, N-Myc tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
2955 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 762C/T not causing the amino acid variation.
描述
Full length Clone DNA of Human colony stimulating factor 1receptor (CSF1R) with N terminal Myc tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-SP-N-Myc
限制性酶切位点
KpnI(two restriction sites) + XbaI(6kb+1.31kb+1.65kb)
标签序列
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
CSF1R cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CSF1R cDNA ORF Clone, Human, N-Myc tag Validated Images
Human CSF1R Gene Plasmid Map 19039
CSF1R cDNA ORF Clone, Human, N-Myc tag Alternative Names
C-FMS cDNA ORF Clone, Human;CD115 cDNA ORF Clone, Human;CSF-1R cDNA ORF Clone, Human;CSFR cDNA ORF Clone, Human;FIM2 cDNA ORF Clone, Human;FMS cDNA ORF Clone, Human;HDLS cDNA ORF Clone, Human;M-CSF-R cDNA ORF Clone, Human;MCSF Receptor cDNA ORF Clone, Human
CSF1R Background Information

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

Full Name
colony stimulating factor 1 receptor
References
  • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
  • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
  • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
  • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
  • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
  • CSF1R cDNA ORF Clone, Canine, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Canine DG70086-G
    CSF1R cDNA ORF Clone, Canine, untagged DG70086-UT
    CSF1R cDNA ORF Clone, Canine, C-GFPSpark® tag DG70086-ACG
    CSF1R Lentiviral cDNA ORF Clone, Canine, C-GFPSpark® tag DG70086-ACGLN
    CSF1R cDNA ORF Clone, Canine, C-OFPSpark® tag DG70086-ACR
    CSF1R cDNA ORF Clone, Canine, C-DDK (Flag®) tag DG70086-CF
    CSF1R cDNA ORF Clone, Canine, N-DDK (Flag®) tag DG70086-NF
    CSF1R cDNA ORF Clone, Canine, C-His tag DG70086-CH
    CSF1R cDNA ORF Clone, Canine, N-His tag DG70086-NH
    CSF1R cDNA ORF Clone, Canine, C-HA tag DG70086-CY
    CSF1R cDNA ORF Clone, Canine, N-HA tag DG70086-NY
    CSF1R cDNA ORF Clone, Canine, C-Myc tag DG70086-CM
    CSF1R cDNA ORF Clone, Canine, N-Myc tag DG70086-NM

    CSF1R cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Rhesus CG90035-G
    CSF1R cDNA ORF Clone, Rhesus, untagged CG90035-UT
    CSF1R cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90035-ACG
    CSF1R Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90035-ACGLN
    CSF1R cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90035-ACR
    CSF1R cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90035-CF
    CSF1R cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90035-NF
    CSF1R cDNA ORF Clone, Rhesus, C-His tag CG90035-CH
    CSF1R cDNA ORF Clone, Rhesus, N-His tag CG90035-NH
    CSF1R cDNA ORF Clone, Rhesus, C-HA tag CG90035-CY
    CSF1R cDNA ORF Clone, Rhesus, N-HA tag CG90035-NY
    CSF1R cDNA ORF Clone, Rhesus, C-Myc tag CG90035-CM
    CSF1R cDNA ORF Clone, Rhesus, N-Myc tag CG90035-NM

    CSF1R cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Mouse MG50059-M
    CSF1R cDNA ORF Clone, Mouse, untagged MG50059-UT
    CSF1R cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50059-ACG
    CSF1R Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50059-ACGLN
    CSF1R cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50059-ACR
    CSF1R cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50059-CF
    CSF1R cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50059-NF
    CSF1R cDNA ORF Clone, Mouse, C-His tag MG50059-CH
    CSF1R cDNA ORF Clone, Mouse, N-His tag MG50059-NH
    CSF1R cDNA ORF Clone, Mouse, C-HA tag MG50059-CY
    CSF1R cDNA ORF Clone, Mouse, N-HA tag MG50059-NY
    CSF1R cDNA ORF Clone, Mouse, C-Myc tag MG50059-CM
    CSF1R cDNA ORF Clone, Mouse, N-Myc tag MG50059-NM
    CSF1R qPCR Primer Pairs, Mouse MP200059

    CSF1R cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Human HG10161-M
    CSF1R cDNA ORF Clone, Human, untagged HG10161-UT
    CSF1R Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10161-ACGLN
    CSF1R cDNA ORF Clone, Human, C-GFPSpark® tag HG10161-ACG
    CSF1R cDNA ORF Clone, Human, C-OFPSpark® tag HG10161-ACR
    CSF1R cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10161-CF
    CSF1R cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10161-NF
    CSF1R cDNA ORF Clone, Human, C-His tag HG10161-CH
    CSF1R cDNA ORF Clone, Human, N-His tag HG10161-NH
    CSF1R cDNA ORF Clone, Human, C-HA tag HG10161-CY
    CSF1R cDNA ORF Clone, Human, N-HA tag HG10161-NY
    CSF1R cDNA ORF Clone, Human, C-Myc tag HG10161-CM
    CSF1R qPCR Primer Pairs, Human HP100231
    info info
    添加购物车成功! 添加购物车失败!