( We provide with MMP3 qPCR primers for gene expression analysis, HP100493 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG10467-ACG|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG10467-ACR|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG10467-CF|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG10467-CH|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG10467-CM|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG10467-CY|
|人 MMP-3 基因ORF全长cDNA(克隆载体)||HG10467-M|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG10467-M-F|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG10467-NF|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG10467-NH|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG10467-NM|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG10467-NY|
|人 MMP-3 基因ORF全长cDNA克隆(表达载体)||HG10467-UT|
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.