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人 Periostin/POSTN/OSF-2 transcript variant 4 基因ORF全长cDNA克隆(表达载体)

  • Human OSF2 / POSTN transcript variant 4 natural ORF mammalian expression plasmid
产品数据评论相关产品实验方法
 POSTN cDNA Clone产品信息
NCBI注册码:NM_001135936.1
参考序列ORF长度:2256bp
cDNA基因描述:Full length Clone DNA of Homo sapiens periostin, osteoblast specific factor, transcript variant 4.
分子别称:Pn, OSF-2, PDLPOSTN, MGC119510, MGC119511, periostin, RP11-412K4.1
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-POSTN
限制性酶切位点:HindIII + NotI (6.1kb + 2.26kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with POSTN qPCR primers for gene expression analysis, HP100342 )
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
 POSTN 基因质粒图
Human OSF2 / POSTN transcript variant 4 natural ORF mammalian expression plasmid
人 Periostin/POSTN/OSF-2 transcript variant 4 基因ORF全长cDNA克隆(表达载体) on other vectors
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研究背景

Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.

参考资料
  • Kudo,Y. et al., 2007, Histol Histopathol. 22 (10):1167-1174.
  • Li, J.S. et al., 2007, World J Gastroenterol. 13 (39): 5261-5266.
  • Oku, E. et al., 2008, Int J Hematol. 88 (1): 57-63.
  • Hamilton, D.W. et al., 2008, J Cell Commun Signal. 2(1-2):9-17.
  • Puglisi, F.J et al., 2008, Clin Pathol. 61 (4): 494-498.
  • Conway, S. J. et al., 2008, Curr Genomics. 9 (8): 548-555.
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    货号: HG10299-UT
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