OSTM1 cDNA ORF Clone, Human, N-DDK (Flag®) tag

Cat: HG10913-NF

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OSTM1 cDNA ORF Clone, Human, N-DDK (Flag®) tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
1005 bp
描述
Full length Clone DNA of Human osteopetrosis associated transmembrane protein 1 with N terminal Flag tag.

质粒

启动子
Enhanced CMV promoter
标签序列
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

OSTM1 cDNA ORF Clone, Human, N-DDK (Flag®) tag Alternative Names

GIPN cDNA ORF Clone, Human;GL cDNA ORF Clone, Human;HSPC019 cDNA ORF Clone, Human;OPTB5 cDNA ORF Clone, Human

OSTM1 Background Information

Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I  membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).

Full Name
osteopetrosis associated transmembrane protein 1
References

1.  Chalhoub, N. et al., 2003, Nat Med. 9 (4): 399-406.

2.  Quarello, P. et al., 2004, J Bone Miner Res. 19 (7): 1194-1199.

3.  Lange, PF. et al., 2006, Nature. 440 (7081): 220-223

4.  Maranda, B. et al., 2008, J Bone Miner Res. 23 (2): 296-300.

5.  Feigin, ME.et al., 2008, Cell Signal. 20 (5): 949-957.  

6.  Pata, M.et al., 2008, J Biol Chem. 283 (45): 30522-30530. 

OSTM1 cDNA ORF Clone, Mouse, Related Products

Product Name Catalog#(PDF)
OSTM1 cDNA ORF Clone in Cloning Vector, Mouse MG51952-G
OSTM1 cDNA ORF Clone, Mouse, untagged MG51952-UT
OSTM1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51952-ACGLN
OSTM1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51952-ACG
OSTM1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG51952-ACR
OSTM1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG51952-CF
OSTM1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG51952-NF
OSTM1 cDNA ORF Clone, Mouse, C-His tag MG51952-CH
OSTM1 cDNA ORF Clone, Mouse, N-His tag MG51952-NH
OSTM1 cDNA ORF Clone, Mouse, C-HA tag MG51952-CY
OSTM1 cDNA ORF Clone, Mouse, N-HA tag MG51952-NY
OSTM1 cDNA ORF Clone, Mouse, C-Myc tag MG51952-CM
OSTM1 cDNA ORF Clone, Mouse, N-Myc tag MG51952-NM
OSTM1 qPCR Primer Pairs, Mouse MP201825

OSTM1 cDNA ORF Clone, Human, Related Products

Product Name Catalog#(PDF)
OSTM1 cDNA ORF Clone in Cloning Vector, Human HG10913-M
OSTM1 cDNA ORF Clone, Human, untagged HG10913-UT
OSTM1 cDNA ORF Clone, Human, C-GFPSpark® tag HG10913-ACG
OSTM1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10913-ACGLN
OSTM1 cDNA ORF Clone, Human, C-OFPSpark® tag HG10913-ACR
OSTM1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10913-CF
OSTM1 cDNA ORF Clone, Human, C-His tag HG10913-CH
OSTM1 cDNA ORF Clone, Human, N-His tag HG10913-NH
OSTM1 cDNA ORF Clone, Human, C-HA tag HG10913-CY
OSTM1 cDNA ORF Clone, Human, N-HA tag HG10913-NY
OSTM1 cDNA ORF Clone, Human, C-Myc tag HG10913-CM
OSTM1 cDNA ORF Clone, Human, N-Myc tag HG10913-NM
OSTM1 qPCR Primer Pairs, Human HP100796
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