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人 PLA2G2A 基因ORF全长cDNA克隆(表达载体)

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Human PLA2G2A cDNA Clone产品信息
NCBI注册码:NM_000300.2
参考序列ORF长度:435bp
cDNA基因描述:Full length Clone DNA of Homo sapiens phospholipase A2, group IIA (platelets, synovial fluid).
分子别称:MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2, PLA2G2A
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-PLA2G2A
限制性酶切位点:KpnI + XbaI (6.1kb + 0.44kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence except for the point mutation 96 G/C not causing the amino acid variation.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicilin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Human PLA2G2A 基因质粒图
Human PLA2G2A Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
Product nameProduct name
研究背景

Phospholipase A2, membrane associated, also known as Phosphatidylcholine 2-acylhydrolase 2A, Group IIA phospholipase A2, Non-pancreatic secretory phospholipase A2 and PLA2G2A, is a peripheral membrane protein which belongs to the phospholipase A2 family. PLA2G2A is found in many cells and also extracellularly. The membrane-bound and secreted forms of PLA2G2A are identical. PLA2G2A has been proposed to play a role in anti-bacterial defense, inflammation and eicosanoid generation, in clearance of apoptotic cells, and in the Wnt signaling pathway. PLA2G2A is thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. PLA2G2A catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. PLA2G2A might be a factor in human colorectal tumorigenesis.

参考资料
  • Praml,C. et al., 1998, Oncogene. 17 (15):2009-12.
  • Fijneman,R.J. et al., 2008,Front Biosci 13 :4144-74.
  • Fijneman,R.J. et al., 2009, Cell Oncol  31 (5):345-56.
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    货号: HG11187-UT
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    • Human PLA2G2A Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
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