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人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-His 标签

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Human RELA cDNA Clone产品信息
NCBI注册码:NM_021975
参考序列ORF长度:1656bp
cDNA基因描述:Full length Clone DNA of Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian) with C terminal His tag.
分子别称:p65
分子种属:Human
载体:pCMV3-C-His
质粒:pCMV3-RELA-His
限制性酶切位点:KpnI + XbaI (6kb + 1.7kb)
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列信息:Identical with the Gene Bank Ref. ID sequence.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Kanamycin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Human RELA 基因质粒图
Human RELA / Transcription factor p65 / NFkB p65 ORF mammalian expression plasmid, C-His tag
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-His 标签 on other vectors
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签HG12054-ACG2070
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签HG12054-ACR2070
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-GFPSpark 标签HG12054-ANG2070
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-OFPSpark 标签HG12054-ANR2070
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-Flag 标签HG12054-CF1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-His 标签HG12054-CH1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-Myc 标签HG12054-CM1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), C-HA 标签HG12054-CY1890
人 RELA / Transcription factor p65 基因ORF全长cDNA(克隆载体)HG12054-G920
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-Flag 标签HG12054-NF1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-His 标签HG12054-NH1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-Myc 标签HG12054-NM1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体), N-HA 标签HG12054-NY1890
人 RELA / Transcription factor p65 基因ORF全长cDNA克隆(表达载体)HG12054-UT1890
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Product nameProduct name
研究背景

RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.

参考资料
  • Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
  • Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
  • Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.
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    • Human RELA / Transcription factor p65 / NFkB p65 ORF mammalian expression plasmid, C-His tag
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