|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG10466-ACG|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG10466-ACR|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG10466-CF|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG10466-CH|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG10466-CM|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG10466-CY|
|人 Nogo Receptor 基因ORF全长cDNA(克隆载体)||HG10466-M|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG10466-NF|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG10466-NH|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG10466-NM|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG10466-NY|
|人 Nogo Receptor 基因ORF全长cDNA克隆(表达载体)||HG10466-UT|
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
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