|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG11104-ACG|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG11104-ACR|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG11104-CF|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG11104-CH|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG11104-CM|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG11104-CY|
|人 PEDF 基因ORF全长cDNA(克隆载体)||HG11104-M|
|人 PEDF 基因ORF全长cDNA克隆(表达载体)||HG11104-M-N|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG11104-NF|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG11104-NH|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG11104-NM|
|人 PEDF 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG11104-NY|
|人 PEDF 基因ORF全长cDNA克隆(表达载体)||HG11104-UT|
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.