SAP cDNA ORF Clone, Human, C-HA tag

Cat: HG11149-CY
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All SAP Reagents
CRO Services
Product recommended

All SAP Reagents
SAP cDNA ORF Clone, Human, C-HA tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
387 bp
描述
Full length Clone DNA of Human SH2 domain protein 1A with C terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-HA
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SAP cDNA ORF Clone, Human, C-HA tag Alternative Names
DSHP cDNA ORF Clone, Human;EBVS cDNA ORF Clone, Human;IMD5 cDNA ORF Clone, Human;LYP cDNA ORF Clone, Human;MTCP1 cDNA ORF Clone, Human;SAP cDNA ORF Clone, Human;SAP/SH2D1A cDNA ORF Clone, Human;XLP cDNA ORF Clone, Human;XLPD cDNA ORF Clone, Human;XLPD1 cDNA ORF Clone, Human
SAP Background Information

SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome. 

Full Name
SH2 domain containing 1A
References
  • Morra M, et al. (2005) Defective B cell responses in the absence of SH2D1A. PNAS. 102 (13): 4819-23.
  • Morra M, et al. (2001) Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients. The Journal of Biological Chemistry. 276: 36809-16.
  • Hron JD, et al. (2004) SH2D1A Regulates T-dependent Humoral Autoimmunity. JEM. 200 (2): 261-6.
  • SAP cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    SAP cDNA ORF Clone in Cloning Vector, Human HG11149-M
    SAP cDNA ORF Clone in Cloning Vector, Human HG16976-U
    SAP cDNA ORF Clone, Human, untagged HG16976-UT
    SAP cDNA ORF Clone, Human, untagged HG11149-UT
    SAP cDNA ORF Clone, Human, C-GFPSpark® tag HG11149-ACG
    SAP Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11149-ACGLN
    SAP Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG16976-ACGLN
    SAP cDNA ORF Clone, Human, C-GFPSpark® tag HG16976-ACG
    SAP cDNA ORF Clone, Human, N-GFPSpark® tag HG11149-ANG
    SAP cDNA ORF Clone, Human, N-GFPSpark® tag HG16976-ANG
    SAP cDNA ORF Clone, Human, C-OFPSpark® tag HG16976-ACR
    SAP cDNA ORF Clone, Human, C-OFPSpark® tag HG11149-ACR
    SAP cDNA ORF Clone, Human, N-OFPSpark® tag HG16976-ANR
    SAP cDNA ORF Clone, Human, N-OFPSpark® tag HG11149-ANR
    SAP cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11149-CF
    SAP cDNA ORF Clone, Human, C-DDK (Flag®) tag HG16976-CF
    SAP cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11149-NF
    SAP cDNA ORF Clone, Human, N-DDK (Flag®) tag HG16976-NF
    SAP cDNA ORF Clone, Human, C-His tag HG11149-CH
    SAP cDNA ORF Clone, Human, C-His tag HG16976-CH
    SAP cDNA ORF Clone, Human, N-His tag HG11149-NH
    SAP cDNA ORF Clone, Human, N-His tag HG16976-NH
    SAP cDNA ORF Clone, Human, C-HA tag HG16976-CY
    SAP cDNA ORF Clone, Human, N-HA tag HG16976-NY
    SAP cDNA ORF Clone, Human, N-HA tag HG11149-NY
    SAP cDNA ORF Clone, Human, C-Myc tag HG11149-CM
    SAP cDNA ORF Clone, Human, C-Myc tag HG16976-CM
    SAP cDNA ORF Clone, Human, N-Myc tag HG16976-NM
    SAP cDNA ORF Clone, Human, N-Myc tag HG11149-NM
    SAP qPCR Primer Pairs, Human HP101058
    info info
    添加购物车成功! 添加购物车失败!