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人 SMOC-1 基因ORF全长cDNA克隆(表达载体)

  • other Green fluorescent protein / GFP Gene Plasmid Map 5613
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 SMOC1 cDNA Clone产品信息
NCBI注册码:NM_001034852.1
参考序列ORF长度:1308bp
cDNA基因描述:Full length Clone DNA of Homo sapiens SPARC related modular calcium binding 1.
分子别称:SMOC1
分子种属:Human
载体:pCMV3-untagged
质粒:pCMV3-SMOC1
限制性酶切位点:KpnI + XbaI(6kb+1.31kb)
Tag序列:
序列信息:Identical with the Gene Bank Ref. ID sequence except for the point mutations: 126G/A,702C/T not causing the amino acid variation.
测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with SMOC1 qPCR primers for gene expression analysis, HP101562 )
启动子:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
抗生素(大肠杆菌):Ampicillin
抗生素(哺乳动物细胞):Hygromycin
运输方式:Each tube contains lyophilized plasmid.
储存方法:The lyophilized plasmid can be stored at room temperature for three months.
Product nameProduct name
研究背景

SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow derived mesenchymal stem cells (BMSCs) through paracrine or autocrine mechanisms. SMOC1 is a regulator of osteoblast differentiation of BMSCs. SMOC1 is highly expressed and secreted in BMSCs stimulated with osteogenic medium (OSM). SMOC1 and SMOC2 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis. SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development.

参考资料
  • Vannahme C. et al., 2002 J. Biol. Chem. 277:37977-86.
  • Pazin,D.E. et al., 2009, Dev Dyn. 238 (11): 2877-90.
  • Choi,Y.A. et al., 2010, J Proteome Res. 9 (6):2946-56.
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    货号: HG12026-UT
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