|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|人 SNCA 基因全长ORF克隆 (表达载体), C端GFPSpark标签||HG12093-ACG|
|人 SNCA 基因全长ORF克隆 (表达载体), C端OFPSpark标签||HG12093-ACR|
|人 SNCA 基因全长ORF克隆 (表达载体), N端GFPSpark标签||HG12093-ANG|
|人 SNCA 基因全长ORF克隆 (表达载体), N端OFPSpark标签||HG12093-ANR|
|人 SNCA 基因全长ORF克隆 (表达载体), C端FLAG标签||HG12093-CF|
|人 SNCA 基因全长ORF克隆 (表达载体), C端His标签||HG12093-CH|
|人 SNCA 基因全长ORF克隆 (表达载体), C端Myc标签||HG12093-CM|
|人 SNCA 基因全长ORF克隆 (表达载体), C端HA标签||HG12093-CY|
|人 SNCA 基因全长ORF克隆||HG12093-G|
|人 SNCA 基因全长ORF克隆 (表达载体), N端FLAG标签||HG12093-NF|
|人 SNCA 基因全长ORF克隆 (表达载体), N端His标签||HG12093-NH|
|人 SNCA 基因全长ORF克隆 (表达载体), N端Myc标签||HG12093-NM|
|人 SNCA 基因全长ORF克隆 (表达载体), N端HA标签||HG12093-NY|
|人 SNCA 基因全长ORF克隆 (表达载体), 无标签||HG12093-UT|
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.