SerpinD1 cDNA ORF Clone, Human, untagged

Cat: HG10295-UT

Contact us:

215-583-7898
order@sinobiological.com
Distributors

All SerpinD1 Reagents

CRO Services

Product recommended


All SerpinD1 Reagents

SerpinD1 cDNA ORF Clone, Human, untagged 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
1500 bp
序列描述
Identical with the Gene Bank Ref. ID sequence except for a point mutation 1446 T/C not causing the amino acid variation.
描述
Full length Clone DNA of Human serpin peptidase inhibitor, clade D (heparin-cofactor), member 1.

质粒

启动子
Enhanced CMV promoter
限制性酶切位点
KpnI + XbaI (6.1kb + 1.5kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Ampicillin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

SerpinD1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SerpinD1 cDNA ORF Clone, Human, untagged Validated Images

other Green fluorescent protein / GFP Gene Plasmid Map 5613

SerpinD1 cDNA ORF Clone, Human, untagged Alternative Names

D22S673 cDNA ORF Clone, Human;HC2 cDNA ORF Clone, Human;HCF2 cDNA ORF Clone, Human;HCII cDNA ORF Clone, Human;HLS2 cDNA ORF Clone, Human;LS2 cDNA ORF Clone, Human;SerpinD1 cDNA ORF Clone, Human;THPH10 cDNA ORF Clone, Human

SerpinD1 Background Information

SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

Full Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
References
  • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
  • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
  • SerpinD1 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    SerpinD1 cDNA ORF Clone in Cloning Vector, Mouse MG50121-M
    SerpinD1 cDNA ORF Clone, Mouse, untagged MG50121-UT
    SerpinD1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50121-ACGLN
    SerpinD1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50121-ACG
    SerpinD1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50121-ACR
    SerpinD1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50121-CF
    SerpinD1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50121-NF
    SerpinD1 cDNA ORF Clone, Mouse, C-His tag MG50121-CH
    SerpinD1 cDNA ORF Clone, Mouse, N-His tag MG50121-NH
    SerpinD1 cDNA ORF Clone, Mouse, C-HA tag MG50121-CY
    SerpinD1 cDNA ORF Clone, Mouse, N-HA tag MG50121-NY
    SerpinD1 cDNA ORF Clone, Mouse, C-Myc tag MG50121-CM
    SerpinD1 cDNA ORF Clone, Mouse, N-Myc tag MG50121-NM
    SerpinD1 qPCR Primer Pairs, Mouse MP200151

    SerpinD1 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    SerpinD1 cDNA ORF Clone in Cloning Vector, Human HG10295-M
    SerpinD1 cDNA ORF Clone, Human, C-GFPSpark® tag HG10295-ACG
    SerpinD1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10295-ACGLN
    SerpinD1 cDNA ORF Clone, Human, C-OFPSpark® tag HG10295-ACR
    SerpinD1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10295-CF
    SerpinD1 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10295-NF
    SerpinD1 cDNA ORF Clone, Human, C-His tag HG10295-CH
    SerpinD1 cDNA ORF Clone, Human, N-His tag HG10295-NH
    SerpinD1 cDNA ORF Clone, Human, C-HA tag HG10295-CY
    SerpinD1 cDNA ORF Clone, Human, N-HA tag HG10295-NY
    SerpinD1 cDNA ORF Clone, Human, C-Myc tag HG10295-CM
    SerpinD1 cDNA ORF Clone, Human, N-Myc tag HG10295-NM
    SerpinD1 qPCR Primer Pairs, Human HP100340
    info info
    添加购物车成功! 添加购物车失败!