Transferrin Receptor / TFRC cDNA ORF Clone, Human, N-His tag

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Transferrin Receptor / TFRC cDNA ORF Clone, Human, N-His tag: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
2328 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 2169G/A not causing the amino acid variation.
产品特征
Full length Clone DNA of Human transferrin receptor (p90, CD71) with N terminal His tag.
质粒
启动子
Enhanced CMV promoter
载体
限制性酶切位点
HindIII(two restriction sites) + NotI(6kb+0.87kb+1.48kb)
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

Transferrin Receptor / TFRC cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Transferrin Receptor / TFRC cDNA ORF Clone, Human, N-His tag: 验证图片

Transferrin Receptor / TFRC cDNA ORF Clone, Human, N-His tag: 别称

CD71 cDNA ORF Clone, Human; p90 cDNA ORF Clone, Human; T9 cDNA ORF Clone, Human; TFR cDNA ORF Clone, Human; TFR1 cDNA ORF Clone, Human; TR cDNA ORF Clone, Human; TRFR cDNA ORF Clone, Human

Transferrin Receptor / TFRC 背景信息

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
全称
transferrin receptor
参考文献
  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
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