( We provide with TGFB1 qPCR primers for gene expression analysis, HP100717 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||HG10804-ACG|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||HG10804-ACR|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||HG10804-CF|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-His 标签||HG10804-CH|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||HG10804-CM|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), C-HA 标签||HG10804-CY|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA(克隆载体)||HG10804-G|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||HG10804-NF|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), N-His 标签||HG10804-NH|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||HG10804-NM|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体), N-HA 标签||HG10804-NY|
|人 TGF-beta 1/TGFB1 基因ORF全长cDNA克隆(表达载体)||HG10804-UT|
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.