DR5 cDNA ORF Clone, Human, C-His tag

Cat: HG10465-CH
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All DR5 Reagents
CRO Services
Product recommended

All DR5 Reagents
DR5 cDNA ORF Clone, Human, C-His tag 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
1323 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human tumor necrosis factor receptor superfamily, member 10b with C terminal His tag.
质粒
启动子
Enhanced CMV promoter
载体
pCMV3-C-His
限制性酶切位点
KpnI + NotI (6kb + 1.37kb)
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
DR5 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

DR5 cDNA ORF Clone, Human, C-His tag Validated Images
Human IL12A / IL-12A Gene Plasmid Map 5643
DR5 cDNA ORF Clone, Human, C-His tag Alternative Names
CD262 cDNA ORF Clone, Human;DR5 cDNA ORF Clone, Human;KILLER cDNA ORF Clone, Human;KILLER/DR5 cDNA ORF Clone, Human;TRAIL-R2 cDNA ORF Clone, Human;TRAILR2 cDNA ORF Clone, Human;TRICK2 cDNA ORF Clone, Human;TRICK2A cDNA ORF Clone, Human;TRICK2B cDNA ORF Clone, Human;TRICKB cDNA ORF Clone, Human;ZTNFR9 cDNA ORF Clone, Human
DR5 Background Information

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 10b
References
  • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
  • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
  • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.
  • DR5 cDNA ORF Clone, Cynomolgus, Related Products

    Product Name Catalog#(PDF)
    DR5 cDNA ORF Clone in Cloning Vector, Cynomolgus CG90870-G

    DR5 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    DR5 cDNA ORF Clone in Cloning Vector, Mouse MG50412-G
    DR5 cDNA ORF Clone, Mouse, untagged MG50412-UT
    DR5 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50412-ACGLN
    DR5 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50412-ACG
    DR5 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50412-ACR
    DR5 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50412-CF
    DR5 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50412-NF
    DR5 cDNA ORF Clone, Mouse, C-His tag MG50412-CH
    DR5 cDNA ORF Clone, Mouse, N-His tag MG50412-NH
    DR5 cDNA ORF Clone, Mouse, C-HA tag MG50412-CY
    DR5 cDNA ORF Clone, Mouse, N-HA tag MG50412-NY
    DR5 cDNA ORF Clone, Mouse, C-Myc tag MG50412-CM
    DR5 cDNA ORF Clone, Mouse, N-Myc tag MG50412-NM
    DR5 qPCR Primer Pairs, Mouse MP200074

    DR5 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    DR5 cDNA ORF Clone in Cloning Vector, Human HG10465-M
    DR5 cDNA ORF Clone, Human, untagged HG10465-UT
    DR5 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10465-ACGLN
    DR5 cDNA ORF Clone, Human, C-GFPSpark® tag HG10465-ACG
    DR5 cDNA ORF Clone, Human, C-OFPSpark® tag HG10465-ACR
    DR5 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10465-CF
    DR5 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10465-NF
    DR5 cDNA ORF Clone, Human, N-His tag HG10465-NH
    DR5 cDNA ORF Clone, Human, C-HA tag HG10465-CY
    DR5 cDNA ORF Clone, Human, N-HA tag HG10465-NY
    DR5 cDNA ORF Clone, Human, C-Myc tag HG10465-CM
    DR5 cDNA ORF Clone, Human, N-Myc tag HG10465-NM
    DR5 qPCR Primer Pairs, Human HP100049
    info info
    添加购物车成功! 添加购物车失败!