C-MPL cDNA ORF Clone, Human, C-His tag

Cat: HG10443-CH

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C-MPL cDNA ORF Clone, Human, C-His tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
1908 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human myeloproliferative leukemia virus oncogene with C terminal His tag.

质粒

启动子
Enhanced CMV promoter
载体
限制性酶切位点
KpnI (two restriction sites) + XbaI (6kb + 0.99kb + 0.98kb)
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

C-MPL cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

C-MPL cDNA ORF Clone, Human, C-His tag Validated Images

Human c-MPL / CD110 / TPOR Gene Plasmid Map 5707

C-MPL cDNA ORF Clone, Human, C-His tag Alternative Names

C-MPL cDNA ORF Clone, Human;CD110 cDNA ORF Clone, Human;MPLV cDNA ORF Clone, Human;THCYT2 cDNA ORF Clone, Human;TPOR cDNA ORF Clone, Human

C-MPL Background Information

CD110, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for c-mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopeniawhich is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.

Full Name
MPL proto-oncogene, thrombopoietin receptor
References
  • Vigon I., et al.,(1992), Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 89:5640-5644.
  • Mignotte V., et al., (1994), Structure and transcription of the human c-mpl gene (MPL).Genomics 20:5-12.
  • Gregory S.G., et al.,(2006), The DNA sequence and biological annotation of human chromosome 1.Nature 441:315-321.
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