14-3-3 epsilon cDNA ORF Clone, Human, C-HA tag

Cat: HG10842-CY

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14-3-3 epsilon cDNA ORF Clone, Human, C-HA tag 基本信息

基因

种属
Human
NCBI 参考序列号
参考序列ORF长度
768 bp
描述
Full length Clone DNA of Human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

14-3-3 epsilon cDNA ORF Clone, Human, C-HA tag Alternative Names

14-3-3E cDNA ORF Clone, Human;HEL2 cDNA ORF Clone, Human;KCIP-1 cDNA ORF Clone, Human;MDCR cDNA ORF Clone, Human;MDS cDNA ORF Clone, Human

14-3-3 epsilon Background Information

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
References
  • Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
  • Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
  • Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.
  • 14-3-3 epsilon cDNA ORF Clone, Rat, Related Products

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    14-3-3 epsilon cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Mouse MG50691-G
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    14-3-3 epsilon cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50691-CF
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    14-3-3 epsilon cDNA ORF Clone, Mouse, C-His tag MG50691-CH
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-His tag MG50691-NH
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-HA tag MG50691-CY
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-HA tag MG50691-NY
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    14-3-3 epsilon cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Human HG10842-M
    14-3-3 epsilon cDNA ORF Clone, Human, untagged HG10842-UT
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    14-3-3 epsilon cDNA ORF Clone, Human, C-GFPSpark® tag HG10842-ACG
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    14-3-3 epsilon cDNA ORF Clone, Human, N-OFPSpark® tag HG10842-ANR
    14-3-3 epsilon cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10842-CF
    14-3-3 epsilon cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10842-NF
    14-3-3 epsilon cDNA ORF Clone, Human, C-His tag HG10842-CH
    14-3-3 epsilon cDNA ORF Clone, Human, N-His tag HG10842-NH
    14-3-3 epsilon cDNA ORF Clone, Human, N-HA tag HG10842-NY
    14-3-3 epsilon cDNA ORF Clone, Human, C-Myc tag HG10842-CM
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    14-3-3 epsilon qPCR Primer Pairs, Human HP100740
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