Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G / RSV-G ORF mammalian expression plasmid (Codon Optimized)

Cat: VG40041-UT

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All RSV Glycoprotein G Reagents

Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G / RSV-G ORF mammalian expression plasmid (Codon Optimized) 基本信息

基因

种属
RSV
参考序列ORF长度
897 bp
序列描述
A number of silent mutations were introduced into the DNA sequence in order to increase its protein expression level in mammalian cell system. The translated amino acid sequence is identical with P20895.2.
描述
Full length Clone DNA of Human RSV (subtype A, strain Long) glycoprotein G / RSV-G.

质粒

启动子
Enhanced CMV promoter
限制性酶切位点
KpnI + XbaI (6.1kb + 0.9kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Ampicillin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

RSV Glycoprotein G cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G / RSV-G ORF mammalian expression plasmid (Codon Optimized) Validated Images

other Green fluorescent protein / GFP Gene Plasmid Map 5613

Human respiratory syncytial virus (RSV) (subtype A, strain Long) glycoprotein G / RSV-G ORF mammalian expression plasmid (Codon Optimized) Alternative Names

G cDNA ORF Clone, RSV

RSV Glycoprotein G Background Information

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 80-90 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.

References
  • Martin-Gallardo A. et al., 1993, J Gen Virol. 74 : 453-8.
  • Jose AM. et al.,1997, J Gen Virol. 78: 2411-8.
  • Feldman SA. et al., 1999, J Virol. 73: 6610-7.
  • García-Beato R. et al., 2000, J Gen Virol. 81: 919-27.
  • Zlateva KT. et al., 2004, J Virol. 78: 4675-83.
  • Trento A. et al., 2006, J Virol. 80: 975-84.
  • RSV Glycoprotein G cDNA ORF Clone, RSV, Related Products

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