ICOS ligand Matched ELISA Antibody Pair Set,Human

Cat: SEK11559
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ICOS ligand Matched ELISA Antibody Pair Set,Human General Information
Product name
ICOS ligand Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human ICOS ligand
Assay range
62.5-4000
Materials provided
1. Capture Antibody 0.5 mg/mL of mouse anti-Human ICOS Ligand / B7-H2 / ICOSLG monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 11559-MM05)
2. Detection Antibody 0.2 mg/mL of mouse anti-Human ICOS Ligand / B7-H2 / ICOSLG monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use. (Catalog: # 11559-MM07)
3. Standard Each vial contains 82 ng of recombinant Human ICOS Ligand / B7-H2 / ICOSLG. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 4000 pg/mL is recommended.
Product overview
This ICOS ligand Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human ICOS ligand . It contains Human ICOS ligand capture antibody, Human ICOS ligand detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human ICOS ligand protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
ICOS ligand Matched ELISA Antibody Pair Set,Human Images
Human ICOSL/ICOS ligand/B7-h2 ELISA Pair Set Standard Curve 13934
ICOS ligand Matched ELISA Antibody Pair Set,Human Alternative Names
B7-h2 Matched ELISA Antibody Pair Set, Human;B7H2 Matched ELISA Antibody Pair Set, Human;B7RP-1 Matched ELISA Antibody Pair Set, Human;B7RP1 Matched ELISA Antibody Pair Set, Human;CD275 Matched ELISA Antibody Pair Set, Human;GL50 Matched ELISA Antibody Pair Set, Human;ICOS ligand Matched ELISA Antibody Pair Set, Human;ICOS-L Matched ELISA Antibody Pair Set, Human;ICOSL Matched ELISA Antibody Pair Set, Human;ICOSLG Matched ELISA Antibody Pair Set, Human;LICOS Matched ELISA Antibody Pair Set, Human
ICOS ligand Background Information

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
inducible T-cell co-stimulator ligand
References
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
  • Product Description Assay Range (pg/ml) Sample Type Catalog# (PDF)
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