ICOS ligand (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)
All ICOS ligand reagents are produced in house and quality controlled, including 13 ICOS ligand Antibody, 1 ICOS ligand ELISA, 28 ICOS ligand Gene, 7 ICOS ligand Lysate, 9 ICOS ligand Protein, 2 ICOS ligand qPCR. All ICOS ligand reagents are ready to use.
All ICOS ligand Reagents
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ICOS ligand Protein (9)Recombinant ICOS ligand proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc & His, C-His, C-human IgG1-Fc.
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ICOS ligand Antibody (13)ICOS ligand antibodies are validated with different applications, which are FCM, ELISA, WB, ELISA(Det), IHC-P, ELISA(Cap).
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ICOS ligand ELISA Kit (1)ICOS ligand ELISA Kits are quality controlled by 8 internation QC standards which guarantee every ELISA Kit with high quality.
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ICOS ligand Lysate (7)ICOS ligand overexpression lysate was created in HEK293, HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of ICOS ligand protein from the overexpression lysate was verified.
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ICOS ligand cDNA Clone (28)ICOS ligand cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ICOS ligand of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
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ICOS ligand qPCR Primer (2)Verified forward and reverse primers for analyzing the quantitative expression of gene. The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480.
ICOS ligand 基本信息
ICOS ligand Protein (9)
ICOS ligand Antibody (13)
ICOS ligand ELISA 试剂盒（即用型）& ELISA 抗体对套装（非即用型）(1)
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线性范围: 62.5-4000
ICOS ligand cDNA Clone (28)
NM_001283050.1
In expression vector
NM_015259.4
In expression vector
In lentiviral vector
NM_015790.3
克隆载体 cDNA 产品
In expression vector
In lentiviral vector
XM_006256262.1
克隆载体 cDNA 产品
XM_005548562.3
克隆载体 cDNA 产品
ICOS ligand qPCR Primer (2)
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ICOS ligand qPCR Primer Pairs, Human HP101424
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ICOS ligand qPCR Primer Pairs, Mouse MP200220
ICOS ligand Lysate (7)
ICOS ligand 分子背景
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
- Cancer Immunotherapy
- Co-stimulatory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
ICOS ligand 参考文献
- Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
- Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
- Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
