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All ICOS ligand reagents are produced in house and quality controlled, including 12 ICOS ligand Antibody, 1 ICOS ligand ELISA, 28 ICOS ligand Gene, 7 ICOS ligand Lysate, 9 ICOS ligand Protein, 2 ICOS ligand qPCR. All ICOS ligand reagents are ready to use.
Recombinant ICOS ligand proteins are expressed by HEK293 Cells, HEK293 with fusion tags as C-His, C-human IgG1-Fc & His, C-human IgG1-Fc.
ICOS ligandantibodies are validated with different applications, which are WB, ELISA, ELISA(Det), FCM, ELISA(Cap).
ICOS ligandcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ICOS ligand of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ICOS ligandELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: HEK293
Expression host: HEK293 Cells
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Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
Immune Checkpoint
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets
