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ICOSL/ICOS ligand/B7-h2  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
11559-H08H-200
11559-H08H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
11559-H02H-200
11559-H02H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
50190-M03H-200
50190-M03H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
50190-M08H-200
50190-M08H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
81346-R08H-50
81346-R08H-200
50 µg 
200 µg 
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表达宿主: Human Cells  
90800-C08H-20
90800-C08H-100
20 µg 
100 µg 
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ICOSL/ICOS ligand/B7-h2 相关研究领域

ICOSL/ICOS ligand/B7-h2 相关信号通路

    ICOSL/ICOS ligand/B7-h2 概述&蛋白信息

    ICOSL/ICOS ligand/B7-h2 研究背景

    亚细胞定位: Membrane; Single-pass type I membrane protein (By similarity).
    组织特异性: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
    诱导: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.
    相似的序列: Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    General information above from UniProt

    Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    ICOSL/ICOS ligand/B7-h2 别称

    ICOSL/ICOS ligand/B7-h2 相关文献

  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
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