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IFN-alpha / IFNA1 / IFN 抗体, 鼠单抗

产品数据评论相关产品实验方法
Rat IFNA1 抗体产品信息
免疫原:Recombinant Rat IFN-alpha / IFNA1 / IFN protein (Catalog#80174-R08H)
克隆号:02
Ig 类型:Mouse IgG1
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS
抗体制备方法:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IFN-alpha / IFNA1 / IFN (rh IFN-alpha / IFNA1 / IFN; Catalog#80174-R08H; P05011; Met1-Ser192). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
Rat IFNA1 抗体使用指导
特异性:Rat IFN-alpha / IFNA1 / IFN
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
推荐应用:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat IFN-alpha / IFNA1 / IFN. The detection limit for Rat IFN-alpha / IFNA1 / IFN is approximately 0.078 ng/well.

储存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IFNA1 抗体 Products
IFN-alpha / IFNA1 / IFN 研究背景

IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs can activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they also increase the ability of uninfected host cells to resist new infection by virus.Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon is produced by mitogen- or antigen-stimulated T lymphocytes. IFNA1 is produced by macrophages and has antiviral activities.

Rat IFN-alpha / IFNA1 / IFN 参考资料
  • Takayama I, et al. (2012) The nucleocapsid protein of measles virus blocks host interferon response. Virology. 424(1):45-55.
  • Vairo D, et al. (2011) Severe impairment of IFN-? and IFN-? responses in cells of a patient with a novel STAT1 splicing mutation. Blood. 118(7):1806-17.
  • Bhattacharya S, et al. (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN? via accelerating the degradation of its receptor. Blood. 118(15):4179-87.
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    货号: 80174-MM02-100
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