IFNAR1 Matched ELISA Antibody Pair Set,Human

Cat: SEK13222

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IFNAR1 Matched ELISA Antibody Pair Set,Human General Information

Product name
IFNAR1 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human IFNAR1
Assay range
78.13-5000
Materials provided
1. Capture Antibody 0.5 mg/mL of mouse anti-IFNAR1 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 13222-MM11)
2. Detection Antibody 0.2 mg/mL mouse anti-IFNAR1 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-protector, pH 7.4). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use. (Catalog: # 13222-MM05)
3. Standard Each vial contains 95 ng of recombinant IFNAR1. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 5 ng/mL is recommended.
Product overview
This IFNAR1 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human IFNAR1 . It contains Human IFNAR1 capture antibody, Human IFNAR1 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human IFNAR1 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

IFNAR1 Matched ELISA Antibody Pair Set,Human Images

Human IFNAR1 ELISA Pair Set Standard Curve 13971

IFNAR1 Matched ELISA Antibody Pair Set,Human Alternative Names

AVP Matched ELISA Antibody Pair Set, Human;IFN-alpha-REC Matched ELISA Antibody Pair Set, Human;IFNAR Matched ELISA Antibody Pair Set, Human;IFNBR Matched ELISA Antibody Pair Set, Human;IFRC Matched ELISA Antibody Pair Set, Human

IFNAR1 Background Information

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Full Name
interferon (alpha, beta and omega) receptor 1
References
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
  • Product Description Assay Range (pg/ml) Sample Type Catalog# (PDF)
    IFNAR1 Matched ELISA Antibody Pair Set,Mouse 125 pg/ml SEK50469
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