IL-15 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL-15 reagents are produced in house and quality controlled, including 6 IL-15 Antibody, 1 IL-15 ELISA, 52 IL-15 Gene, 3 IL-15 Protein, 3 IL-15 qPCR. All IL-15 reagents are ready to use.

IL-15 Protein (3)

IL-15 Antibody (6)

IL-15 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

IL-15 cDNA Clone (52)

NM_172174.2

克隆载体 cDNA 产品

In lentiviral vector

NM_008357.1

克隆载体 cDNA 产品

In lentiviral vector

NM_013129.2

克隆载体 cDNA 产品

In lentiviral vector

NM_001044731.1

克隆载体 cDNA 产品

In lentiviral vector

IL-15 分子背景

The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

IL-15 参考文献

  • Mongini PKA, Gupta R, Boyle E, et al. TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells. Journal of immunology (Baltimore, Md : 1950). 2015;195(3):901-923.