Anti-IL1R2 Antibody
Cat: 10111-MM04
Cat: 10111-MM04
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Anti-IL1R2 Antibody (Mouse Monoclonal 抗体) 产品信息
产品名称
Anti-IL1R2 Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human IL1R2
No cross-reactivity in ELISA with
Human IL1RA
Human IL1R1
Human IL1R3
Human IL1R4
Human IL1R8
Human IL1R9
Human IL18R1
No cross-reactivity in ELISA with
Human IL1RA
Human IL1R1
Human IL1R3
Human IL1R4
Human IL1R8
Human IL1R9
Human IL18R1
免疫原
Recombinant Human IL1R2 protein (Catalog#10111-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1R2 / CD121b (rh IL-1R2 / CD121b; Catalog#10111-H08H; NP_004624.1; Met 1-Glu 343). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #7H4D4F8
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-IL1R2 Antibody (Mouse Monoclonal 抗体) 经验证的应用
| 应用 | 推荐稀释比/用量 |
|---|---|
| ELISA | 1:1000-1:2000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-IL1R2 Antibody: 别称
Anti-CD121b Antibody; Anti-CDw121b Antibody; Anti-IL-1R-2 Antibody; Anti-IL-1RT-2 Antibody; Anti-IL-1RT2 Antibody; Anti-IL1R2c Antibody; Anti-IL1RB Antibody
IL1R2 背景信息
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
全称
interleukin 1 receptor, type II
研究领域
- Stem Cells>>Hematopoietic Progenitors>>Myeloid>>Dendritic Cell Lineage
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-1 Family
- Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 Family & Receptor>>IL-1 Family Receptor
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Cytokines & Chemoki and Receptors>>IL-12 Family
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Disorders Therapeutic Targets>>Inflammatory Bowel Diseases Therapeutic Targets
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory mediators
- Immunology>>Innate Immunity>>Cytokine>>Interleukins
- Immunology>>Cluster of Differentiation (CD)>>Monocyte/Macrophage CD Antigen>>Macrophage Marker CD Antigen
- Immunology>>Cluster of Differentiation (CD)>>Monocyte/Macrophage CD Antigen>>Monocyte Marker CD Antigen
- Immunology>>Inflammation / Inflammatory Mediator>>Neuroinflammation
- Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Disorders Therapeutic Targets>>Rheumatoid arthritis Therapeutic Targets
- Stem Cells>>Hematopoietic Progenitors>>Lymphoid>>T Lymphocytic Lineage
参考文献
- Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
- Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
- Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
