IL-4 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL-4 reagents are produced in house and quality controlled, including 12 IL-4 Antibody, 2 IL-4 ELISA, 60 IL-4 Gene, 1 IL-4 Lysate, 6 IL-4 Protein, 3 IL-4 qPCR. All IL-4 reagents are ready to use.

IL-4 Protein (6)

IL-4 Antibody (12)

IL-4 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

IL-4 cDNA Clone (60)

BC067514

In lentiviral vector

NM_021283.1

克隆载体 cDNA 产品

In lentiviral vector

NM_201270.1

克隆载体 cDNA 产品

In lentiviral vector

In expression vector

NM_001032904.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001003159.1

克隆载体 cDNA 产品

In lentiviral vector

IL-4 Lysate (1)

更多受客户欢迎的产品

IL-4 分子背景

Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and for the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as of other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibites in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and of the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.

IL-4 参考文献

  • Grunewald SM. et al., 1998, J Immunol. 160 (8): 4004-9.
  • Susanne M. et al, 1997, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 272 (3): 1480-3.
  • Nishikubo K. et al., 2003, Gene Ther. 10 (26): 2119-25.