IL-6 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL-6 reagents are produced in house and quality controlled, including 24 IL-6 Antibody, 2 IL-6 ELISA, 66 IL-6 Gene, 1 IL-6 IP Kit, 6 IL-6 Protein, 3 IL-6 qPCR. All IL-6 reagents are ready to use.

IL-6 Protein (6)

IL-6 Antibody (24)

IL-6 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

IL-6 cDNA Clone (66)

NM_000600.2

克隆载体 cDNA 产品

In lentiviral vector

NM_031168.1

克隆载体 cDNA 产品

In lentiviral vector

NM_012589.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001042733.1

克隆载体 cDNA 产品

In lentiviral vector

NM_001003301.1

克隆载体 cDNA 产品

In lentiviral vector

IL-6 分子背景

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

IL-6 参考文献

  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.