IL-6R (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL-6R reagents are produced in house and quality controlled, including 15 IL-6R Antibody, 4 IL-6R ELISA, 41 IL-6R Gene, 6 IL-6R Lysate, 7 IL-6R Protein, 2 IL-6R qPCR. All IL-6R reagents are ready to use.

IL-6R Protein (7)

IL-6R Antibody (15)

IL-6R ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

IL-6R cDNA Clone (41)

NM_000565.2

克隆载体 cDNA 产品

In lentiviral vector

NM_010559.2

克隆载体 cDNA 产品

In lentiviral vector

NM_017020.3

克隆载体 cDNA 产品

XM_001114404.2

克隆载体 cDNA 产品

In lentiviral vector

XM_850012.3

克隆载体 cDNA 产品

IL-6R Lysate (6)

IL-6R 分子背景

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp13. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp13 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

IL-6R 参考文献

  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.