IL10RB (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All IL10RB reagents are produced in house and quality controlled, including 11 IL10RB Antibody, 2 IL10RB ELISA, 52 IL10RB Gene, 5 IL10RB Lysate, 5 IL10RB Protein, 3 IL10RB qPCR. All IL10RB reagents are ready to use.

IL10RB 分子背景

Interleukin 1 receptor, beta subunit (IL1RB/IL-1RB) also known as Cytokine receptor family 2 member 4, Interleukin-1 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-1 receptor. IL1RB/IL-1RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 1 receptor complex. Coexpression of this and IL1RA proteins has been shown to be required for IL1-induced signal transduction. Defects in IL1RB/IL-1RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

IL10RB 参考文献

  • Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
  • Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.