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IL13RA2 / IL13R 抗体, 兔多抗, 抗原亲和纯化

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大鼠 IL13RA2 抗体产品信息
免疫原:Recombinant Rat IL13RA2 / IL13R protein (Catalog#80204-R08H)
克隆号:
Ig 类型:Rabbit IgG
浓度:
内毒素:
缓冲液:0.2 μm filtered solution in PBS with 5% trehalose
抗体制备方法:Produced in rabbits immunized with purified, recombinant Rat IL13RA2 / IL13R (rR IL13RA2 / IL13R; Catalog#80204-R08H; Q8VHK6; Met1-Lys336). IL13RA2 / IL13R specific IgG was purified by Rat IL13RA2 / IL13R affinity chromatography.
大鼠 IL13RA2 抗体IHC实验图片
IL13RA2 / IL13R Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of rat IL13RA2 in rat brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
IL13RA2 / IL13R Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of rat IL13RA2 in rat liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
IL13RA2 / IL13R Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of rat IL13RA2 in rat spleen with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
IL13RA2 / IL13R Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[点击查看大图]
Caption:
Immunochemical staining of rat IL13RA2 in rat stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other IL13RA2 抗体 Products
IL13RA2 / CD213A2 研究背景

Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.

大鼠 IL13RA2 / CD213A2 参考资料
  • Zhou G, et al.. (2005) Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 79(9): 5272-7.
  • Osawa M, et al.. (2000) Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics. 51(11): 974-81.
  • Nair BG, et al.. (2011) Nanotechnology platforms; an innovative approach to brain tumor therapy. Med Chem. 7(5): 488-503.
  • Benson M, et al.. (2006) A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 118(1): 220-5.
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    货号: 80204-RP02-50
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