IL17RA Protein, Mouse, Recombinant (Fc Tag)

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IL17RA Protein, Mouse, Recombinant (Fc Tag): 产品信息

纯度
(14.8+80.1) % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Measured by its binding ability in a functional ELISA.
Immobilized mouse IL17A (Cat:51065-MNAE) at 10 μg/ml (100 μl/well) can bind mouse IL17RA-Fc (cat: 50328-M02H), The EC50 of mouse IL17RA-Fc (cat: 50328-M02H) is 0.28-0.64 μg/ml.
蛋白构建
A DNA sequence encoding the mouse IL17RA (Q60943)(Met1-Trp322) was expressed with the Fc region of human IgG1 at the C-terminus.
NCBI Reference No.
表达宿主
HEK293 Cells
种属
Mouse
预测 N 端
Ser 32
分子量
The recombinant mouse IL17RA/Fc is a disulfide-linked homodimer. The reduced monomer comprises 532 amino acids and has a predicted molecular mass of 60.3 kDa. The apparent molecular mass of the protein is approximately 67-77 and 118 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL17RA Protein, Mouse, Recombinant (Fc Tag): 图片

IL17RA Protein, Mouse, Recombinant (Fc Tag): 别称

AW538159 Protein, Mouse; Cdw217 Protein, Mouse; Il17r Protein, Mouse; VDw217 Protein, Mouse

IL17RA 背景信息

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
全称
interleukin 17 receptor A
参考文献
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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