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小鼠 IL18RAP / IL1R7 蛋白 (His 标签)

  • Mouse IL18RAP / IL1R7 Protein (His Tag) SDS-PAGE
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小鼠 IL18RAP 蛋白产品信息
分子别称:AcPL,IL-18R-beta,IL-18RAcP,IL-18Rbeta,IL-1RAcPL
蛋白构建:A DNA sequence encoding the mouse IL18RAP (NP_034683.1) (Met1-Glu356) was expressed with a C-terminal polyhistidine tag.
分子种属:Mouse
表达宿主:Baculovirus-Insect cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
小鼠 IL18RAP 蛋白质控检测
纯度:> 95 % as determined by SDS-PAGE
生物活性:Measured by its binding ability in a functional ELISA.
Immobilized mouse IL18RAP-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse IL18 (Cat:50073-MNCE), The EC50 of biotinylated mouse IL18 (Cat:50073-MNCE) is 10.6-25.0 μg/ml.
内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Phe 20
分子量:The recombinant mouse IL18RAP comprises 348 amino acids and has a predicted molecular mass of 40.1 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions.
缓冲液:Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
小鼠 IL18RAP 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
小鼠 IL18RAP 蛋白SDS-PAGE
Mouse IL18RAP / IL1R7 Protein (His Tag) SDS-PAGE

IL18RAP 相关信号通路

Other IL18RAP 蛋白 Products
IL18RAP 研究背景

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

小鼠 IL18RAP 参考资料
  • Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
  • Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
  • Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.
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    货号: 50845-M08B-50
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