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IL7/IL-7/Interleukin-7  蛋白,抗体,试剂盒,cDNA克隆

表达宿主: E. coli  
11821-HNAE-20
11821-HNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表达宿主: E. coli  
50217-MNAE-20
50217-MNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
表达宿主: E. coli  
80329-RNAE-20
80329-RNAE-10
20 µg 
10 µg 
Add to Cart
  • Slide 1

IL7/IL-7/Interleukin-7 相关研究领域

IL7/IL-7/Interleukin-7 相关蛋白、抗体、cDNA基因、ELISA试剂盒

IL7/IL-7/Interleukin-7 概述&蛋白信息

IL7/IL-7/Interleukin-7 研究背景

基因概述: The protein encoded by this IL7 gene is a cytokine important for B and T cell development. IL7e and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that IL7 plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
General information above from NCBI
亚细胞定位: Secreted.
相似的序列: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
General information above from UniProt

IL7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL7/IL-7/Interleukin-7 别称

IL-7, [homo-sapiens]
IL7,IL-7,interleukin 7, [human]
A630026I06Rik,hlb368,Il7,Il-7,interleukin 7, [mouse]
Il-7,hlb368,A630026I06Rik, [mus-musculus]

IL7/IL-7/Interleukin-7 相关文献

  • Watanabe M, et al. (1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.
  • J Clin Invest. 95(6):2945-53. Sawa Y, et al. (2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57.
  • Flad HD, et al. (1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 26(10): 2541-4.
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