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ILT6 / LILRA3 抗体, 兔多抗

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     LILRA3 抗体产品信息
    免疫原:Recombinant Human ILT6 / LILRA3 protein (Catalog#13549-H08H)
    克隆号:
    Ig 类型:Rabbit IgG
    浓度:
    内毒素:
    缓冲液:0.2 μm filtered solution in PBS
    抗体制备方法:Produced in rabbits immunized with purified, recombinant Human ILT6 / LILRA3 (rh LILRA3; Catalog#13549-H08H; AAH28208.1; Met1-Glu439). Total IgG was purified by Protein A affinity chromatography.
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    LILRA3/CD85e/ILT6 研究背景

    ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

     LILRA3/CD85e/ILT6 参考资料
  • Wi?niewski A, et al. (2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61.
  • Norman PJ, et al. (2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71.
  • Cella M, et al. (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.
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