Anti-LILRA3 Antibody

Cat: 13549-RP01
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Anti-LILRA3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-LILRA3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LILRA3
Immunogen
Recombinant Human ILT6 / LILRA3 protein (Catalog#13549-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ILT6 / LILRA3 (rh LILRA3; Catalog#13549-H08H; AAH28208.1; Met1-Glu439). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LILRA3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-LILRA3 Antibody Alternative Names
Anti-CD85e Antibody;Anti-HM31 Antibody;Anti-HM43 Antibody;Anti-ILT-6 Antibody;Anti-ILT6 Antibody;Anti-LIR-4 Antibody;Anti-LIR4 Antibody
LILRA3 Background Information

ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

Full Name
leukocyte immunoglobulin like receptor A3
References
  • Wi?niewski A, et al. (2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61.
  • Norman PJ, et al. (2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71.
  • Cella M, et al. (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-LILRA3 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 13549-MM06
    Anti-LILRA3 Antibody Rabbit Monoclonal FCM 13549-R060
    Anti-LILRA3 Antibody (PE) Rabbit Monoclonal FCM 13549-R060-P
    Anti-LILRA3 Antibody (FITC) Rabbit Monoclonal FCM 13549-R060-F
    Anti-LILRA3 Antibody Rabbit Polyclonal ELISA 13549-T16
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