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甲型流感 H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) 血凝素 (Hemagglutinin / HA) 蛋白 (His 标签)

  • H17N10 HA Protein 15106
H17N10 HA 蛋白产品信息
分子别称:Hemagglutinin, HA
蛋白构建:A DNA sequence encoding the Influenza A virus (A/little yellow-shouldered bat/Guatemala/164/2009 (H17N10)) hemagglutinin (AFC35418.1) (Met1-Tyr527), termed as HA, was expressed with a polyhistidine tag at the C-terminus.
表达宿主:Baculovirus-Insect Cells
运输说明:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
H17N10 HA 蛋白质控检测
纯度:> 95 % as determined by SDS-PAGE.
内毒素:< 1.0 EU per μg protein as determined by the LAL method.
稳定性:Samples are stable for up to twelve months from date of receipt at -70℃
预测N端:Asp 19
分子量:The recombinant hemagglutinin of Influenza A virus (A/little yellow-shouldered bat/Guatemala/164/2009 (H17N10)) consists of 520 amino acids and predicts a molecular mass of 59 kDa.
缓冲液:Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
H17N10 HA 蛋白使用指导
储存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶条件:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

HA 相关信号通路

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    HA 研究背景

    The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA0, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA0) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.

    H17N10 HA 参考资料
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). "Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential". Avian Dis. 40 (2): 425–37
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