Cytokeratin 14 / KRT14 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Cytokeratin 14 / KRT14 reagents are produced in house and quality controlled, including 5 Cytokeratin 14 / KRT14 Antibody, 45 Cytokeratin 14 / KRT14 Gene, 2 Cytokeratin 14 / KRT14 IP Kit, 2 Cytokeratin 14 / KRT14 qPCR. All Cytokeratin 14 / KRT14 reagents are ready to use.

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Cytokeratin 14 / KRT14 分子背景

Cytokeratin 14, also known as Keratin 14 and K14, is a member of the keratin family. Cytokeratin 14 is a type I keratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Cytokeratin 14 is mainly expressed in the basal layer. It is also strongly expressed in the outer root sheath of anagen follicles. Cytokeratin 14 and keratin 5 may have a role in maintenance of cell proliferation potential in the basal layer of stratified epithelia, modulating phosphatidylinositol 3-kinase/Akt–mediated cell proliferation and/or Notch1-dependent cell differentiation. Cytokeratin 14 defect prevents it from working effectively with keratin 5 and interfering with the assembly of the keratin intermediate filament network. A disruption in this network makes keratinocytes fragile and prone to rupture. Minor trauma to the skin, such as rubbing or scratching, can cause these cells to break down, resulting in the formation of painful, fluid-filled blisters. Mutations in the K14 gene are also responsible for Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis.

Cytokeratin 14 / KRT14 参考文献

  • Coulombe PA, et al., 1991, Cell. 66(6): 1301-11.
  • Schweizer J, et al., 2006, 174(2): 169-74.
  • Lugassy J, et al., 2006, Am J Hum Genet. 79(4): 724-30.