LAIR1 cDNA ORF Clone in Cloning Vector, Human

Cat: HG13257-G
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All LAIR1 Reagents
CRO Services
Product recommended

All LAIR1 Reagents
LAIR1 cDNA ORF Clone in Cloning Vector, Human 基本信息
基因
种属
Human
NCBI 参考序列号
参考序列ORF长度
864 bp
序列描述
Identical with the Gene Bank Ref. ID sequence.
描述
Full length Clone DNA of Human leukocyte-associated immunoglobulin-like receptor.
质粒
载体
pGEM-T Vector
测序引物
SP6 and T7 or M13-47 and RV-M
质控
The plasmid is confirmed by full-length sequencing.
筛选
抗生素(大肠杆菌)
Ampicillin
储存 & 运输
运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.
LAIR1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

LAIR1 cDNA ORF Clone in Cloning Vector, Human Alternative Names
CD305 cDNA ORF Clone, Human;LAIR-1 cDNA ORF Clone, Human
LAIR1 Background Information

Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. 

Full Name
leukocyte-associated immunoglobulin-like receptor 1
References
  • Meyaard L, et al. (1999) Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 162 (10): 5800-4.
  • Meyaard L, et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194 (1): 107-12.
  • Xu M, et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275 (23): 17440-6.
  • LAIR1 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    LAIR1 cDNA ORF Clone in Cloning Vector, Rat RG80415-G
    LAIR1 cDNA ORF Clone, Rat, untagged RG80415-UT
    LAIR1 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80415-ACGLN
    LAIR1 cDNA ORF Clone, Rat, C-GFPSpark® tag RG80415-ACG
    LAIR1 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80415-ACR
    LAIR1 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80415-CF
    LAIR1 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80415-NF
    LAIR1 cDNA ORF Clone, Rat, C-His tag RG80415-CH
    LAIR1 cDNA ORF Clone, Rat, N-His tag RG80415-NH
    LAIR1 cDNA ORF Clone, Rat, C-HA tag RG80415-CY
    LAIR1 cDNA ORF Clone, Rat, N-HA tag RG80415-NY
    LAIR1 cDNA ORF Clone, Rat, C-Myc tag RG80415-CM
    LAIR1 cDNA ORF Clone, Rat, N-Myc tag RG80415-NM
    LAIR1 qPCR Primer Pairs, Rat RP300379

    LAIR1 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    LAIR1 cDNA ORF Clone, Human, untagged HG13257-UT
    LAIR1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG13257-ACGLN
    LAIR1 cDNA ORF Clone, Human, C-GFPSpark® tag HG13257-ACG
    LAIR1 cDNA ORF Clone, Human, C-OFPSpark® tag HG13257-ACR
    LAIR1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG13257-CF
    LAIR1 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG13257-NF
    LAIR1 cDNA ORF Clone, Human, C-His tag HG13257-CH
    LAIR1 cDNA ORF Clone, Human, N-His tag HG13257-NH
    LAIR1 cDNA ORF Clone, Human, C-HA tag HG13257-CY
    LAIR1 cDNA ORF Clone, Human, N-HA tag HG13257-NY
    LAIR1 cDNA ORF Clone, Human, C-Myc tag HG13257-CM
    LAIR1 cDNA ORF Clone, Human, N-Myc tag HG13257-NM
    LAIR1 qPCR Primer Pairs, Human HP101966

    LAIR1 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    LAIR1 qPCR Primer Pairs, Mouse MP200989
    info info
    添加购物车成功! 添加购物车失败!