Lck (Protein|Antibody|cDNA Clone|ELISA Kit)

All Lck reagents are produced in house and quality controlled, including 3 Lck Antibody, 30 Lck Gene, 1 Lck Lysate, 1 Lck Protein, 1 Lck qPCR. All Lck reagents are ready to use.

Recombinant Lck proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST.

Lckantibodies are validated with different applications, which are ELISA, WB, IHC-P.

LckcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Lck of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Lck Protein (1)

Species

Lck Protein, Human, Recombinant (GST Tag)

10043-H09B

Expression host: Baculovirus-Insect Cells

Human Lck Protein 8328
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Lck Antibody (3)

Application Clonality
Host

Anti-Lck Antibody

10043-RP01

Application: ELISA

Clonality: PAb

Anti-Lck Antibody

100817-T32

Application: WB

Clonality: PAb

Human Lck Western blot (WB) 6523

Anti-Lck Antibody

10043-T56

Application: WB,ELISA,IHC-P

Clonality: PAb

Human Lck Western blot (WB) 15210
Go

Lck cDNA Clone (30)

Human
Mouse

Lck qPCR Primer (1)

Lck Lysate (1)

Protein kinases are critically involved in signaling pathways that regulate cell growth, differentiation, activation, and survival. Initially identified as a T-cell specific member of the Src family of protein tyrosine kinases, Lck has become the object of intensive investigations which have revealed a key role for this kinase in the central processes controlling T-cell development, activation, proliferation and survival. Lck is expressed specifically in lymphoid cells. It contains one protein kinase domain, one SH2 domain, and one SH3 domain. It is associated with a variety of cell surface receptors and is critical for signal transduction from the T-cell antigen receptor (TCR). Consequently, Lck is targeted by regulatory proteins of T-lymphotropic viruses, especially by the Herpesvirus saimiri (HVS) tyrosine kinase interacting protein (Tip). This oncoprotein physically interacts with Lck in HVS transformed T cells and has an impact on its catalytic activity. Together with the identification of defects in the regulation of Lck expression or activity in T-cell leukemias, suggests that dysregulation of Lck might play a role in neoplastic transformation. However, under certain conditions Lck is also involved in the induction of apoptosis. This chemosensitizing effect of Lck is independent of T-cell receptor signaling and does not require the kinase activity of Lck. The findings demonstrate that Lck might be part of two independent signaling pathways leading to either cell proliferation or apoptosis.

Protein
Antibody
Gene
qPCR
Lysate
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