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MMP-14/MMP14  蛋白,抗体,试剂盒,cDNA克隆

MMP-14/MMP14 相关研究领域

MMP-14/MMP14 相关信号通路

    MMP-14/MMP14 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    MMP-14/MMP14 概述&蛋白信息

    MMP-14/MMP14 研究背景

    催化活性: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
    辅因子: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    亚单位结构: Interacts (via C-terminal cytoplasmic tail) with BST2. {ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:9724659}.
    结构域: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    亚细胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
    组织特异性: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
    诱导: Up-regulated by NANOS1. {ECO:0000269|PubMed:18223680}.
    翻译后修饰: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.; Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
    相关疾病 : DISEASE: Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269|PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-14/MMP14 别称

    MMP-14/MMP14 相关文献

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