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MMP-8 / MMP8  蛋白,抗体,试剂盒,cDNA克隆

描述: Active  
表达宿主: Human Cells  
  • Slide 1
10254-HNAH-20
10254-HNAH-10
20 µg 
10 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10254-H08H-20
10254-H08H-10
20 µg 
10 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
50493-MNAH-20
50493-MNAH-10
20 µg 
10 µg 
Add to Cart
表达宿主: CHO Stable Cells  
  • Slide 1
50493-M08S-20
50493-M08S-10
20 µg 
10 µg 
Add to Cart

MMP-8 / MMP8 相关研究领域

MMP-8 / MMP8 相关信号通路

    MMP-8 / MMP8 概述&蛋白信息

    MMP-8 / MMP8 研究背景

    基因概述: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by MMP8 gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
    辅因子: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 3 Ca(2+) ions per subunit.;; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
    酶调控: ENZYME REGULATION: Cannot be activated without removal of the activation peptide.
    亚单位结构: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).
    结构域: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    亚细胞定位: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.
    组织特异性: Neutrophils.
    相似的序列: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-8 / MMP8 别称

    MMP-8 / MMP8 相关文献

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