MAX / MYC associated factor X (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All MAX / MYC associated factor X reagents are produced in house and quality controlled, including 5 MAX / MYC associated factor X Antibody, 30 MAX / MYC associated factor X Gene, 2 MAX / MYC associated factor X IP Kit, 1 MAX / MYC associated factor X Lysate, 1 MAX / MYC associated factor X Protein. All MAX / MYC associated factor X reagents are ready to use.

MAX / MYC associated factor X Protein (1)

    MAX / MYC associated factor X Antibody (5)

      MAX / MYC associated factor X cDNA Clone (30)

      NM_145112.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001146176.1

      克隆载体 cDNA 产品

      In lentiviral vector

      MAX / MYC associated factor X Lysate (1)

        MAX / MYC associated factor X 分子背景

        MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to MAX family. It is highly expressed in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. MYC associated factor X can form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. MYC associated factor X may also repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Multiple alternatively spliced transcript variants have been described for MYC associated factor X gene but the full-length nature for some of them is unknown.

        MAX / MYC associated factor X 参考文献

        • Mac Partlin M, et al. (2003) Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX. Oncogene. 22(6):819-25.
        • Cheng SW, et al. (1999) c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nat enet. 22(1):102-5.
        • McMahon SB, et al. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. 94(3):363-74.

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