( We provide with AXL qPCR primers for gene expression analysis, MP200156 )
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||MG50126-ACG|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||MG50126-ACR|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||MG50126-CF|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-His 标签||MG50126-CH|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||MG50126-CM|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), C-HA 标签||MG50126-CY|
|小鼠 AXL 基因ORF全长cDNA(克隆载体)||MG50126-M|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||MG50126-NF|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), N-His 标签||MG50126-NH|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||MG50126-NM|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体), N-HA 标签||MG50126-NY|
|小鼠 AXL 基因ORF全长cDNA克隆(表达载体)||MG50126-UT|
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.