BTLA qPCR Primer Pairs, Mouse

Cat: MP201030
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BTLA qPCR Primer Pairs, Mouse 基本信息
Target Details
种属:
Mouse
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
应用:
SYBR® Green-based quantitative real-time PCR (qPCR).
质控:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
储存 & 运输
运输:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
储存:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
BTLA qPCR Primer Pairs, Mouse Alternative Names
A630002H24 qPCR Primer Pairs, Mouse
BTLA Background Information

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

Immune Checkpoint
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
B and T lymphocyte associated
References
  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
  • BTLA qPCR Primer Pairs, Rhesus, Related Products

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    BTLA cDNA ORF Clone in Cloning Vector, Rhesus CG90250-G
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    BTLA cDNA ORF Clone, Rhesus, C-His tag CG90250-G-H
    BTLA cDNA ORF Clone, Rhesus, N-His tag CG90250-NH
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    BTLA qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    BTLA cDNA ORF Clone in Cloning Vector, Mouse MG51060-U
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    BTLA cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51060-ACG
    BTLA cDNA ORF Clone, Mouse, C-OFPSpark® tag MG51060-ACR
    BTLA cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG51060-CF
    BTLA cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG51060-NF
    BTLA cDNA ORF Clone, Mouse, C-His tag MG51060-CH
    BTLA cDNA ORF Clone, Mouse, N-His tag MG51060-NH
    BTLA cDNA ORF Clone, Mouse, C-HA tag MG51060-CY
    BTLA cDNA ORF Clone, Mouse, N-HA tag MG51060-NY
    BTLA cDNA ORF Clone, Mouse, C-Myc tag MG51060-CM
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    BTLA qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    BTLA cDNA ORF Clone, Human, untagged HG11895-UT
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    BTLA cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11895-CF
    BTLA cDNA ORF Clone, Human, N-HA tag HG11895-NY
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