|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签||MG50503-ACG|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签||MG50503-ACR|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-Flag 标签||MG50503-CF|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-His 标签||MG50503-CH|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-Myc 标签||MG50503-CM|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), C-HA 标签||MG50503-CY|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA(克隆载体)||MG50503-M|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), N-Flag 标签||MG50503-NF|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), N-His 标签||MG50503-NH|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), N-Myc 标签||MG50503-NM|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体), N-HA 标签||MG50503-NY|
|小鼠 CTLA-4/CD152 基因ORF全长cDNA克隆(表达载体)||MG50503-UT|
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).