Decorin cDNA ORF Clone, Mouse, C-HA tag

Cat: MG51501-CY

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Decorin cDNA ORF Clone, Mouse, C-HA tag 基本信息

基因

种属
Mouse
NCBI 参考序列号
参考序列ORF长度
1065 bp
描述
Full length Clone DNA of Mouse decorin with C terminal HA tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Decorin cDNA ORF Clone, Mouse, C-HA tag Alternative Names

DC cDNA ORF Clone, Mouse;DSPG2 cDNA ORF Clone, Mouse;mDcn cDNA ORF Clone, Mouse;PG40 cDNA ORF Clone, Mouse;PGII cDNA ORF Clone, Mouse;PGS2 cDNA ORF Clone, Mouse;SLRR1B cDNA ORF Clone, Mouse

Decorin Background Information

Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.

Full Name
decorin
References
  • Mogyorsi A, et al. (1999) What is the role of decorin in diabetic kidney disease? Nephrol Dial Transplant. 14(5): 1078-81.
  • Reed CC, et al. (2002) The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J. 19(4-5): 249-55.
  • Goldoni S, et al. (2008) Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer. 123(11): 2473-9.
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    Decorin cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    Decorin cDNA ORF Clone in Cloning Vector, Mouse MG51501-U
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    Decorin Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51501-ACGLN
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    Decorin cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    Decorin cDNA ORF Clone in Cloning Vector, Human HG10189-M
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    Decorin cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10189-CF
    Decorin cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10189-NF
    Decorin cDNA ORF Clone, Human, C-His tag HG10189-CH
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