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小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-His 标签

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    小鼠 FGF14 cDNA Clone产品信息
    NCBI注册码:NM_207667.3
    参考序列ORF长度:759bp
    cDNA基因描述:Full length Clone DNA of Mus musculus fibroblast growth factor 14, transcript variant 2 with C terminal His tag.
    分子别称:Fhf4, FHF-4, MGC129318, MGC129319, mFHF-4(1B), Fgf14
    分子种属:Mouse
    载体:pCMV3-C-His
    质粒:
    限制性酶切位点:
    Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
    序列信息:
    测序引物:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with FGF14 qPCR primers for gene expression analysis, MP200210 )
    启动子:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    抗生素(大肠杆菌):Kanamycin
    抗生素(哺乳动物细胞):Hygromycin
    运输方式:Each tube contains lyophilized plasmid.
    储存方法:The lyophilized plasmid can be stored at room temperature for three months.
    His Tag Info

    A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

    Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-His 标签 on other vectors
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-GFPSpark 标签MG50180-ACG1950
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-OFPSpark 标签MG50180-ACR1950
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-GFPSpark 标签MG50180-ANG1950
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-OFPSpark 标签MG50180-ANR1950
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-Flag 标签MG50180-CF1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-His 标签MG50180-CH1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-Myc 标签MG50180-CM1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), C-HA 标签MG50180-CY1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA(克隆载体)MG50180-M760
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-Flag 标签MG50180-NF1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-His 标签MG50180-NH1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-Myc 标签MG50180-NM1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体), N-HA 标签MG50180-NY1770
    小鼠 FGF14/SCA27 transcript variant 2 基因ORF全长cDNA克隆(表达载体)MG50180-UT1770
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    研究背景

    FGF14 is a member of the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 is probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). It is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia. It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

    参考资料
  • Wang Q, et al. (2002) Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron. 35 (1): 25-38.
  • Zhao Y, et al. (2007) Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. Am J Med Genet. 144B (3): 395-6.
  • Lou JY, et al. (2005) Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. J Physiol. 569 (1): 179-93.
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