LAMP2 cDNA ORF Clone, Mouse, C-His tag

Cat: MG50791-CH

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LAMP2 cDNA ORF Clone, Mouse, C-His tag 基本信息

基因

种属
Mouse
NCBI 参考序列号
参考序列ORF长度
1248 bp
描述
Full length Clone DNA of Mouse lysosomal-associated membrane protein 2 with C terminal His tag.

质粒

启动子
Enhanced CMV promoter
载体
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.

筛选

抗生素(大肠杆菌)
Kanamycin
抗生素(哺乳动物细胞)
Hygromycin
应用
Stable or Transient mammalian expression

储存 & 运输

运输
Each tube contains lyophilized plasmid.
储存
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

LAMP2 cDNA ORF Clone, Mouse, C-His tag Alternative Names

CD107b cDNA ORF Clone, Mouse;Lamp-2 cDNA ORF Clone, Mouse;Lamp-2a cDNA ORF Clone, Mouse;Lamp-2b cDNA ORF Clone, Mouse;Lamp-2c cDNA ORF Clone, Mouse;LampII cDNA ORF Clone, Mouse;LGP-B cDNA ORF Clone, Mouse;Mac3 cDNA ORF Clone, Mouse

LAMP2 Background Information

LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.

Full Name
lysosomal-associated membrane protein 2
References
  • Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.
  • Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.
  • Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.
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